Joe, 59, was 'at death's door' ? then a 開拓するing but 実験の pill (警官の)巡回区域,受持ち区域 his 癌 in just six months

患者s 戦う/戦いing incurable leukaemia 血 have been thrown a lifeline ? thanks to an 実験の pill that's been 述べるd as 'like something out of a sci-fi movie'.

In an 早期に 裁判,公判 of the 麻薬 ? which is known as NX-5948, and is so new it doesn't have a 指名する ? a 59-year-old 患者 who had run out of 治療 選択s and had only months to live, has seen his 癌 all but disappear after he began taking the pills.

Joe Murphy, from Hulme, Greater Manchester, is only the second 患者 in the world to be 申し込む/申し出d the 治療 at The Christie NHS 創立/基礎 信用, and he says it brought him '支援する from the brink'.

The former 妨げる/法廷,弁護士業 経営者/支配人 was 診断するd with an 積極的な form of chronic lymphocytic leukaemia (CLL) in 2015, which had recently spread to his spinal fluid and brain.

The 病気, which 原因(となる)s 異常な white 血 独房s to build up in the 血 and bone 骨髄, can at first be controlled using tablets, which 許す 患者s to live for nearly a 10年間 more after diagnosis.

Joe Murphy, from Hulme, Greater Manchester,
 is the second patient in the world to receive the revolutionary new pill and says it brought him 'back from the brink'

Joe Murphy, from Hulme, Greater Manchester, is the second 患者 in the world to receive the 革命の new pill and says it brought him '支援する from the brink'

Mr Murphy was 診断するd with a 高度に 積極的な form of leukaemia, which 許すs 異常な white 血 独房s to build up? in 血 and bone 骨髄 (artist's impression above)

However, over time, the 癌 独房s become 抵抗力のある to 治療s. This means that, for 患者s 診断するd at a younger age, there is a desperate need for more 薬/医学s. CLL kills more than 1,000 people in the UK every year.

Last year, Joe stopped 答える/応じるing to the third 麻薬 he'd been on to 支配(する)/統制する his 癌. He lost more than a 4半期/4分の1 of his bodyweight and , as his 免疫の system 弱めるd, had been hospitalised with sepsis and meningitis.

But today, thanks to the fact he was 申し込む/申し出d the 開拓するing 麻薬, 実験(する)s show almost no 証拠 of 病気. 'I wouldn't be here today if it weren't for the 裁判,公判,' Joe said. 'After the third 治療 failed, I was 準備するing to die. I was not in a good place.

'But this 麻薬 has kept me alive and 井戸/弁護士席 since June last year. It's incredible ? like something out of a sci-fi movie.?

'I'm putting 負わせる 支援する on, my 血 count is 罰金, my lymph nodes have shrunk 支援する to 近づく normal, and it's worked 首尾よく in getting rid of the 癌 in my brain, which is such a 救済.'

While doctors don't know how long it might keep the 病気 at bay, Joe says he is now '希望に満ちた' and can look 今後 to celebrating his 60th birthday in December.

CLL, which 影響する/感情s more than 4,500 Britons every year, is the most ありふれた adult 血 癌 and makes up 38 per cent of all leukaemia 事例/患者s.?

Around 40 per cent are 老年の 75 and older. People with a family history of CLL are more likely to get the 病気.

It is more ありふれた の中で men, for 推論する/理由s that scientists still do not understand.

基準 治療 for CLL 含む inhibitors, which 封鎖する signals that make 癌 独房s grow, immunotherapy, which 作品 by binding to and 殺人,大当り cancerous 独房s, and chemotherapy.?

患者s may also be 申し込む/申し出d combinations of these 治療s, which 熟考する/考慮するs show gives better results. NX-5948, developed by San Francisco-based 麻薬 会社/堅い Nurix 治療力のあるs, is in a new class of 治療s for 血 癌s known as degraders.

They work by taking advantage of the natural 処分 system inside 独房s ? in this 事例/患者, 的ing a 明確な/細部 protein that CLL 癌s need to grow and 'tagging' it to be destroyed.

Dr Emma Searle, 顧問 haematologist at The Christie, who was 主要な/長/主犯 捜査官/調査官 for the 裁判,公判, said: 'This might be the 打開 we've been looking for in the 治療 of CLL.

'The 麻薬 的s a pathway that CLL 独房s are 特に 扶養家族 on and 基本的に blows it up.

'As doctors, we're excited because we're seeing a 返答, even at a low dose, in 患者s who've exhausted all of the 基準 care 選択s and are very difficult to 扱う/治療する.

'To already see some of our 患者s like Joe 答える/応じるing so 井戸/弁護士席 to the 治療, with 小型の mal 味方する-影響s, is very 約束ing.

'Only time will tell whether this makes it to market, but it's about as 約束ing as an 早期に-段階 熟考する/考慮する gets.'

The U.S. regulator, the Food and 麻薬 行政 (FDA), has already 認めるd the 治療 急速な/放蕩な-跡をつける 任命 ? which means 患者s may get 接近 to it more quickly ? because the 早期に results are so 約束ing.

その上の 段階s of the 裁判,公判 are 現在進行中の.

Chronic?lymphocytic leukaemia: the rare form of 癌 that 罠(にかける)s 苦しんでいる人s in a slow death

Chronic lymphocytic leukaemia is a rare form of 癌 that 影響する/感情s the 血 and bone 骨髄.?

The 条件, which develops slowly, is thought to be incurable and becomes more ありふれた as people age - with few 苦しんでいる人s under the age of 40.

The 原因(となる)s of the 条件s are 不明瞭な, although a history of this type of 癌 in the family puts some at a higher 危険.?

Many people who live with lymphocytic leukaemia don't have any symptoms, and if they do, they are not obvious straightaway and can take years to masnifest themselves.?

Many of these symptoms are also ありふれた to other 条件s.?

They 含む:?

  • Swollen (分泌する為の)腺s, usually in your neck or under your 武器
  • Losing 負わせる
  • Getting ill a lot
  • Feeling tired even though you've had a good night's sleep
  • A 無分別な that looks like small bruises or bleeding under the 肌 and does not fade when you roll a glass over it, 類似の to meningitis
  • Bleeding or bruising for no 推論する/理由
  • Looking 異常に pale and feeling breathless
  • A 最高気温 even though you're not unwell
  • Aches and 苦痛s that will not go away
  • Sweating at night

The 条件 may not 要求する 即座の 治療 in some 事例/患者s, and courses of 治療 depends on the 苦しんでいる人s' age, general health and symptoms.?

Main 治療s 伴う/関わるd 的d 薬/医学 to stop the 癌 for growing or to manage symptoms or chemotherapy.

In rare 事例/患者s, 外科 and 放射線療法 can also be advised.?

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