How a long white line on your finger nail could mean you're at a much higher 危険 of 腎臓 CANCER
- READ MORE:??What could YOUR fingernails say about your health?
Faint lines on your fingernail could 示す a rare genetic 条件 that puts you at 危険 of 腎臓, 肌, and 注目する，もくろむ 癌s, new 研究 示唆するs.
Scientists at the 国家の 学校／設けるs of Health (NIH) have discovered that 88 パーセント of people with a rare genetic disorder that can lead to 癌 have?異常な nail 場内取引員／株価s, 含むing a thin white line running the length of the nail.
The genetic disorder, which is believed to run in より小数の than 100 American families, 増加するs the 半端物s of a rare type of 注目する，もくろむ 癌, 同様に as?肺, 肌 and 腎臓 癌.
Called BAP1 tumor predisposition syndrome, it 影響する／感情s a 遺伝子 that 妨げるs the 団体／死体's 独房s from growing at a 早い 率, and developing into tumorous 集まりs.
The 大多数 of people in the 熟考する／考慮する with 異常な nail 場内取引員／株価s such as the thin line running the length of the nail were 設立する to have a benign tumor
Of the total number of people 設立する to a syndrome that predisposes them to 癌, 88 パーセント had tumors in their nail beds
The 遺伝子 also plays a 決定的な 役割 in 修理ing デオキシリボ核酸 損失 to 独房s, which 保護するs against the growth and spread of 癌 独房s.?
The 研究員s happened across the finding in a 熟考する／考慮する looking at the 遺伝子, called?BAP1, for 突然変異s: 41 of 47 people had an 異常な line on a nail, and その上の 調査（する）ing 設立する that 39 of them had a benign tumor.?
Of the total number of people in the 熟考する／考慮する with 確認するd tumor predisposition syndrome, 87.2 パーセント had tumors in their nail beds.
Alexandra Lebensohn, a 国家の 癌 学校／設ける 研究員 who helped 行為／行う the 熟考する／考慮する, said: ‘When asked about nail health during a baseline genetic 査定／評価, a very astute 患者 報告（する）／憶測d that he had noticed subtle changes in his nail.
‘His comment 誘発するd us to systematically 評価する other 関係者s for nail changes and 暴露する this new finding.’
The most 独特の finding was a small, thickened area of 肌 under the nail, along with a white 禁止（する）d running 負かす／撃墜する the nail, which is 一貫した with onychopapilloma, a type of benign tumor.
The tumor is believed to 影響する／感情 the 生産／産物 and 配当 of keratin, the type of protein that makes up the nail.?
The white lines 代表する higher levels of keratinization, or areas where the nail has been 解除するd or distorted by the tumor underneath.??
Thirty-nine of 47 熟考する／考慮する 支配するs were 設立する to have onychopapilloma, most of them males and mostly on the thumbnail. Onychopapilloma is rare in the general 全住民.
Dr Edward Cowen, a dermatologist at NIH's 国家の 学校／設ける of Arthritis and Musculoskeletal and 肌 病気s, said: ‘We believe the presence of nail changes that 示唆する onychopapillomas on 多重の nails should 誘発する consideration of a diagnosis of BAP1 tumor predisposition syndrome.’
Their 研究 was published in JAMA Dermatology.??
The most ありふれた type of 癌 associated with the genetic syndrome was uveal melanoma, or 癌 in the 注目する，もくろむ
About 36 パーセント of people with the genetic disorder have uveal melanoma, a type of 癌 that begins in melanin, which makes dark pigments in the middle 層 of the 塀で囲む of the 注目する，もくろむ. The uvea 含むs the iris.
It accounts for only about 5 パーセント of all 事例／患者s of melanoma in the US.
概略で a ４半期/4分の1 of people with the syndrome have mesothelioma, によれば the NIH. Mesothelioma is an 積極的な 癌 that develops in the thin 層 of tissue that covers most of the 内部の 組織／臓器s, most 一般的に seen in the lining of the 肺s.
And 10 パーセント of people with the 条件 were 設立する to have 腎臓 癌.
BAP1 tumor predisposition syndrome is rare and still under 調査. Around 70 families in the US are known to have the genetic 突然変異 that puts them at higher 危険 for 癌.
Most of the BAP1-関係のある 癌s tend to be more 積極的な and 誘発する／引き起こすd earlier in life.?
In 事例／患者s of malignant mesothelioma, the age of onset in people who are predisposed is 55 years, compared with 72 years for people without that predisposition.
At the same time, several 熟考する／考慮するs have 報告（する）／憶測d that 患者s with a BAP1 突然変異 have an 全体にわたる 生き残り 率 that is seven times longer than those without a genetic predisposition.
