Pregnenolone hormone could 封鎖するマリファナ影響s, scientists discover

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University of Bordeaux 研究員s 設立する the hormone pregnenolone 削減（する）s the brain's sensitivity to THC - the high-inducing 構内／化合物 in cannabis
発見 could lead to new approaches to 扱う／治療するing cannabis dependence
People taking the 麻薬 medicinally could skip its psychoactive 影響s

By Sarah Griffiths

Published: 19:20 BST, 2 January 2014 | Updated: 08:21 BST, 3 January 2014

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A 自然に occurring hormone can be used to stop the ‘high’ produced by cannabis, 研究 has shown.

The 発見 could lead to new approaches to 扱う／治療するing cannabis intoxication and dependence.

It may also 補助装置 in the use of cannabis for medicinal 目的s while 封鎖するing its psychoactive 影響s.

A naturally occurring hormone called pregnenolone can be used to stop the 'high' produced by cannabis and the discovery could lead to new approaches to treating cannabis intoxication and dependence, according to new research

A 自然に occurring hormone called pregnenolone can be used to stop the 'high' produced by cannabis and the 発見 could lead to new approaches to 扱う／治療するing cannabis intoxication and depend ence, によれば new 研究

WHAT IS PREGNENOLONE?

Pregnenolone is a hormone that is 設立する in our 団体／死体s and can be made in the lab.

the 化学製品 is used for 疲労，（軍の）雑役 and 増加するing energy, Alzheimer’s 病気 and 高めるing memory, 外傷／ショック and 傷害s, 同様に as 強調する／ストレス and 改善するing 免疫.

It is also is used for 肌 disorders 含むing psoriasis.

In the 団体／死体, pregnenolone is used to make all steroid hormones.

Because of this, it was 熟考する／考慮するd 熟考する／考慮するd for 強調する／ストレス, 疲労，（軍の）雑役, and arthritis in the 1940s before lab-made hormones became 利用できる.

Source: WebMD

研究員s 設立する that the steroid hormone pregnenolone 減ずるs the brain's sensitivity to THC, which is the 長，指導者 high-inducing 構内／化合物 in cannabis.

Scientists led by Dr Monique Vallee, from the University of Bordeaux in フラン, 熟考する／考慮するd mice and ネズミs to see how recreational 麻薬s such as コカイン, alcohol and cannabis 影響する／感情d the 生産／産物 of steroids in the brain 伴う／関わるd in 神経機能（する）／行事.

They 設立する that THC 誘発する／引き起こすd a 劇の spike in pregnenolone through 活性化 of the cannabinoid receptor (CB-1) - a 分子 that 容易にするs cannabis stimulation.

This in turn had a ‘消極的な feedback’ 影響主要な to a blunting of THC activity, 減ずるing the ‘high’ from the 麻薬.

‘This new understanding of the 役割 of pregnenolone has the 可能性のある to 生成する new therapies for the 治療 of cannabis dependence,’ the scientists said.

The findings, published in the 定期刊行物 Science, follow the 決定／判定勝ち（する） to legalise the recreational use of cannabis in the U.S. 明言する／公表する of Colorado.

Yesterday saw the legalisation of recreational sales of マリファナ in Colorado, where 顧客s 列d to buy an ounce (28.3g) of 合法的な cannabis.

Researchers found that the steroid hormone pregnenolone reduces the brain's sensitivity to THC, which is the chief high-inducing compound in cannabis

研究員s 設立する that the steroid hormone pregnenolone 減ずるs the brain's sensitivity to THC, which is the 長，指導者 high-inducing 構内／化合物 in cannabis

所有／入手, cultivation and 私的な消費 of マリファナ has been 合法的な in the 明言する／公表する since November 2012 but the sale of the 麻薬 from shops 示すs a turning point.

Colorado has 始める，決める up a 工場／植物-跡をつけるing system in a 企て，努力，提案 to 妨げる the 麻薬 from entering the 黒人／ボイコット market, and regulators have 始める，決める up 一括ing, labelling and 実験（する）ing 必要物／必要条件s.

In December, Uruguay became the first country to to make it 合法的な to grow, sell and 消費するマリファナ.

The 法律許すing 登録（する）d Uruguayans over 18 to buy up to 40g (1,4oz) of the 麻薬 a month is 推定する／予想するd to come into 軍隊 in April and the 政府 hopes it will 弱める取り組む麻薬 cartels.

A recent study found teenagers who use cannabis regularly risk damaging their memory as structures in their brains appeared to shrink and collapse inward, possibly reflecting a decrease in neurons

A 最近の熟考する／考慮する設立する十代の少年少女s who use cannabis 定期的に危険損失ing their memory as structures in their brains appeared to 縮む and 崩壊（する） inward, かもしれない反映するing a 減少（する） in neurons

However, while some people believe the legalisation of the 麻薬 will 削減（する）犯罪の activity surrounding it, others believe it will expose more people to 麻薬s, which have been linked to health 問題／発行するs.

A 最近の熟考する／考慮する設立する十代の少年少女s who use cannabis 定期的に危険損失ing their memory, which can lead to poor academic 業績／成果.

They believe the brain abnormalities last for ‘at least a few years’ after 使用者s have stopped taking the 麻薬.

The 研究員s also said there was fresh 証拠 the habit may 原因（となる） mental health problems in youngsters predisposed to schizophrenia.

マリファナ is the most 一般的に used illicit 麻薬の中で adolescents in the UK, with more than four in ten admitting having taken it.

Almost 100 十代の少年少女s took part in the U.S. 研究診察するing the 影響s of cannabis 深い in the brain.

It 設立する十代の少年少女s who smoked it daily for about three years had 異常な changes in the brain structures 関係のある to remembering and 過程ing （警察などへの）密告，告訴（状） and they 成し遂げるd 貧しく on memory 仕事s.

The brain abnormalities and memory problems were 設立する on MRI ざっと目を通すs when 熟考する／考慮する関係者s were in their 早期に twenties ? two years after they had stopped smoking the 麻薬.

Memory-関係のある structures in their brains appeared to 縮む and 崩壊（する） inward and the 研究員s from Northwestern University Feinberg School of 薬／医学, Chicago, said such 損失 was linked to poor academic 業績／成果 and everyday 機能（する）／行事ing.