悲劇 of newlywed, 27, who began 苦しむing from mystery itching... and just 18 months later died from little-known 癌

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Liam Crossley thought he and his fianc?e, Lucy, had a 有望な 未来 ahead of them.?

Lucy, then 27, had just landed her dream 職業 in a lingerie company and he was doing 井戸／弁護士席 as a personal trainer.?

The couple, from 物陰／風下d, were also saving up to get married.

Then, in June, 2013, Lucy suddenly developed a maddening itch all over her 団体／死体, although she could find no 無分別な or bites.

'She was in London training for her new 職業 and called me to tell me about it,' says Liam. 'She was not one to make a fuss, so I knew it must be bad.'

Lucy went to a 減少（する）-in 医療の centre, where they 嫌疑者，容疑者／疑うd she may have scabies (a contagious 条件 原因（となる）d by 肌 mites) and gave her some lotion, but it brought no 救済.

'When she got 支援する home in the first week of July, she was making her 肌 bleed with the scratching,' 解任するs Liam.

'She went to see her own GP who sent her off with antihistamines, thinking the itch could be アレルギー-関係のある.'

In fact, Lucy had neither scabies nor an アレルギー. The itch was a symptom of 癌.

Liam Crossley, now 30, thought he and his fianc?e, Lucy, then 27, had a 有望な 未来 ahead of them

She had a tumour growing in a 胆汁 導管 in her 肝臓, although it would take another four months of going 支援する and 前へ／外へ to the doctor's before she would get a diagnosis.

'The moment they told us she had 癌, she broke 負かす／撃墜する,' says Liam, now 30.

'It was such a 抱擁する shock.

'I tried my best not to cry, too - I 手配中の，お尋ね者 to be strong for her.'

胆汁 導管 癌, or cholangiocarcinoma, is on the rise. In 2010, 1,832 people were 診断するd with it and 1,720 died from it in England. Three years later, 1,965 were 診断するd with it and 2,161 died from it.

'人物／姿／数字s are rising quickly and 意味ありげに,' says Professor Simon Taylor-Robinson, a 顧問 肝臓 specialist and 研究員 at 皇室の College, London.

'支援する in 1968, there were より小数の than 40 事例／患者s a year.

'This is not just 予定 to us getting better at 診断するing it - but we do not know why.'

Today, Liam is struggling to make sense of what happened.?

'I felt so helpless - there was this woman who I 手配中の，お尋ね者 to spend the next 40, 50 or so years with, who was now gone, and there was nothing I could do to save her.

'For three hours after she passed on, I sat there talking to her, apologising for not 存在 able to save her.'

専門家s and charities are calling for more 研究 into and for 増加するd 認識／意識性 of this silent 殺し屋 の中で both the public and 医療の profession.

The 胆汁 導管s are tiny, 支店-like tubes that connect the 肝臓 to the small intestine.

'They are, in 影響, a 汚水 system taking waste 製品s from the 肝臓 into the intestines and out of the 団体／死体,' explains Professor Taylor-Robinson.

These 含む 麻薬s and other toxins that enter the 団体／死体, 同様に as those produced within the 団体／死体 such as bilirubin - which is formed when old red 血 独房s are broken 負かす／撃墜する.

'胆汁 is made up of these waste 製品s, but it is also helpful in digesting fat,' says Professor Taylor-Robinson.

As a tumour grows across a 導管, 胆汁 salts that would normall y be sent to the small intestine build up in the 団体／死体 and get deposited under the 肌, 原因（となる）ing irritation and itching.

Yet often the 病気 remains 'silent' until someone turns yellow with jaundice.

This occurs when bilirubin in the 胆汁 builds up, tingeing the 肌 and tissues yellow.

In 2013 she?suddenly developed a maddening itch all over her 団体／死体. A 減少（する）-in 医療の centre 嫌疑者，容疑者／疑うd she may have scabies and?her own GP sent her off with antihistamines, thinking the itch could be アレルギー-関係のある

胆汁 導管s are tiny - some of them just 8mm wide - and so the tumours that occur within are also minuscule and hard to 位置／汚点／見つけ出す.

'Even MRIs and CT ざっと目を通すs can 行方不明になる them, so of ten it is not 診断するd until the 患者 has jaundice and is 有望な yellow,' says Professor Taylor-Robinson. 'By this time the 癌 is usually inoperable. It starts to spread and often becomes 致命的な.'

癌 of the 胆汁 導管s is linked to 'anything that 原因（となる）s inflammation or chronic irritation in the 胆汁 導管s,' he says.

最初の／主要な sclerosing cholangitis - a form of 肝臓 病気 that can occur in those with the bowel 条件 ulcerative colitis - is a 危険 factor, as are 胆石s, which can get stuck in the 胆汁 導管.

There are 嫌疑者，容疑者／疑うd links with other 条件s such as 非，不，無-アル中患者 fatty 肝臓 病気 and 糖尿病 - both of which are on the rise - but these are not yet fully understood.

'We know that （危険などに）さらす to 確かな 化学製品s produced as a by-製品 of waste incineration may be associated with this 癌 - it has also been associated with 産業の spillage,' says Professor Taylor-Robinson.

Yet why incidences of the 癌 should be 増加するing at such a 率 remains a puzzle.

'It is becoming more ありふれた - the U.S., Japan, Australia, everywhere,' says Professor Taylor-Robinson.

Although it is most ありふれた in the over-60s, the 病気 is becoming ますます frequently seen across all age groups.

'We have heard of children as young as 12 developing it,' says Helen Morement, the 長，指導者 (n)役員／(a)執行力のある of AMMF, the cholangiocarcinoma charity. She believes greater 認識／意識性 could 改善する the prognosis for those unlucky enough to develop the 病気 - at the moment, only 5 per cent are alive five years after diagnosis.

'If people are 繰り返して coming 支援する and 前へ／外へ to the doctor feeling 一般に unwell, we would like doctors to consider 肝臓 機能（する）／行事 実験（する）s, which can help 警報 them to this 病気.'

研究 is under way to develop 血 or urine 実験（する）s that may 選ぶ up the 病気 earlier, and to 改善する imaging techniques to help 位置／汚点／見つけ出す these small tumours.

Lucy went to her GP three times about her itching 肌 before she was referred for an ultra sound.

'By then, her tummy 傷つける and her 肌 was unbearably itchy and yellow,' says Liam.

'They thought she might have 胆石s, but couldn't see anything on the ultrasound - so they referred her 支援する to the GP.'

Then, in late August, by which time she had been 解雇（する）d for taking so much time off sick, she complained of a 強化するing across the chest - referred 苦痛 from the 肝臓 as it turned out - and Liam took her to A&E at Dewsbury hospital, where they did 肝臓 機能（する）／行事 実験（する）s.

'The results were insane,' says Liam. 'Her bilirubin level was 395 - it should be 17.'

They kept her in hospital under 観察 for more than three weeks, but doctors still could not work out what was wrong.

In September, she was moved to St James's Hospital in 物陰／風下d, where she saw five different 顧問s before a ざっと目を通す showed a blockage in her left 胆汁 導管.?

Finally, in October 2013, they were told Lucy had 胆汁 導管 癌.

'I was 持つ／拘留するing her 手渡す as they talked to us, and as soon as they used the word '癌' Lucy broke 負かす／撃墜する and cried into my shoulder.'

The couple managed to bring their wedding 今後 and got married three months before she died

The 癌 was too 前進するd for 外科. All they could 申し込む／申し出 was chemotherapy, which Lucy started in the first week of November.

'She was really 確信して that this would work; not once did she discuss the 可能性 of dying,' says Liam.

She and Liam got married in October 2014 - Lucy was 中途の through her chemotherapy treatament - and Liam treasures the memories of the day.

'She didn't even look ill. She was the most beautiful bride. She didn't feel as if there was anything wrong with her,' he says.

However, two days before Christmas that year, Lucy fainted and was 急ぐd 支援する to hospital in an 救急車.

She was bleeding internally because the tumour was squeezing a vein in her 肝臓. She and Liam were told there was no more they could do to stop the 癌.

'It was the worst thing I have ever heard in my life,' says Liam.

two days after Valentine's Day last year, Lucy went 支援する into hospital to have the vein bypassed, but she never woke up from the anaesthetic and died, 老年の 29, on February 20.

A year on, Liam has bad days and good days.

'No one can really empathise - but I wouldn't want people to feel the way I feel,' he says.

'I just want greater 認識／意識性 of this 病気 and to 妨げる any more people 苦しむing the way Lucy and I did.'

For more （警察などへの）密告，告訴（状）, go to ammf.org.uk

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