Could we end HIV 伝達/伝染s by 2030? Trump is 始める,決める to 発表する ambitious 誓約(する) during 明言する/公表する of the Union - and 専門家s say it's possible

  • Donald Trump is 推定する/予想するd to 誓約(する) to end America's HIV 疫病/流行性の by 2030?
  • That will not mean curing HIV, but we do have the 道具s to end 伝達/伝染
  • We need everyone with HIV to take ウイルス-抑えるing 麻薬s that (after 6 months) make it impossible to 送信する/伝染させる HIV to someone else?
  • People at-危険 of HIV should be taking PrEP, a 麻薬 that 減ずるs 危険 of HIV 伝達/伝染 by 99%
  • 実験(する)ing 率s also need to go up - the CDC 見積(る)s 15% of people with HIV don't know they have it?
  • 基金ing is needed to 上げる all those things - 特に in the South, home to HALF of the country's new HIV 診断するs every year??
  • Here, 専門家s 重さを計る in on the 障害s and how we could 打ち勝つ them by 2030?

Donald Trump is 推定する/予想するd to 発表する a 計画(する) to 'end the HIV 疫病/流行性の by 2030' in his 明言する/公表する of the Union 演説(する)/住所 tonight, によれば a Politico 報告(する)/憶測.

It sounds wildly ambitious, with more than one million Americans living with HIV and 40,000 new 診断するs a year.

But it is not - depending on what he means by 'end'.

There are three ways HIV could be 停止(させる)d, in theory:

  • ending 伝達/伝染s (no one that 契約s HIV will be 'ウイルス-解放する/自由な', but everyone's ウイルス would be 抑えるd by 医薬, and therefore impossible to 送信する/伝染させる)
  • finding a '機能の cure' (the ウイルス would still 存在する but the 免疫の system could be trained to 支配(する)/統制する it without 正規の/正選手 医薬 - 効果的に putting people in remission)
  • finding a 'sterilizing cure' (完全に obliterating the ウイルス, which was done once in the Berlin 患者 in 2007, but could not be replicated).

The 長,率いる of the CDC, long time HIV 研究員 Dr Robert Redfield, believes we can end HIV 伝達/伝染s by 2025.

It's likely that is the 肉親,親類d of 'end' Trump is 想像するing.

But even getting there will 要求する 打ち勝つing some stubborn 障害物s, from 基金ing healthcare services to 取り組むing stigma in 明言する/公表するs where doctors feel uncomfortable about 定める/命ずるing anti-HIV 麻薬s - and more.??

Can we end the HIV epidemic in the US by 2030? Trump is expected to make that pledge

Can we end the HIV 疫病/流行性の in the US by 2030? Trump is 推定する/予想するd to make that 誓約(する)

HOW COULD WE END TRANSMISSIONS?

1. Get more HIV+ people on ウイルス-抑えるing 医薬

In 1996, anti-retroviral therapy was discovered.?

The 麻薬, a 3倍になる combination, turned HIV from a 致命的な diagnosis to a manageable chronic 条件.??

It 抑えるs the ウイルス, 妨げるing it from developing into エイズ (Acquired Immunodeficiency Syndrome), which makes the 団体/死体 unable to withstand 感染s.

Now, 23 years on, it's become (疑いを)晴らす that ART is even more powerful than we 最初 thought: after six months of religiously taking the daily pill, it 抑えるs the ウイルス to such an extent that it's undetectable.?

And once a person's viral 負担 is undetectable, they cannot 送信する/伝染させる HIV to anyone else, によれば 得点する/非難する/20s of 熟考する/考慮するs 含むing a 10年間-long 熟考する/考慮する by the 国家の 学校/設けるs of Health.?

The NIH, the CDC and public health 団体/死体s around the world now 認める that U=U (undetectable equals untransmittable).

Virus-suppressing drugs (after 6 months) make a person's viral load undetectable, and therefore untransmittable

ウイルス-抑えるing 麻薬s (after 6 months) make a person's viral 負担 undetectable, and therefore untransmittable

The challenge is getting people to stay on ART (to remain undetectable), and getting undiagnosed HIV-肯定的な people on ART (the CDC believes 15 パーセント of Americans living with HIV don't know it).?

These 医薬s cannot cure HIV because the ウイルス hides some of itself, lying 活動停止中の in 貯蔵所s in the 団体/死体.?

These 'latent 独房s' are not active, but they are there. If a person stops taking their 薬/医学, these latent 独房s can 開始する a resurgence.

Scientists have worked out a possible avenue for blitzing these 独房s - the 'shock and kill' app roach: waking the latent 独房s up then attacking them.

However, we have yet to work out 正確に/まさに how to wake up the latent 独房s without 致命的な consequences.

2. Get more at-危険 people to take 麻薬s that 妨げる HIV 感染

PrEP (pre-(危険などに)さらす prophylaxis) became 利用できる in 2012.?

This pill 作品 like 'the pill' - it is taken daily and is 99 パーセント 効果的な at 妨げるing HIV 感染 (more 効果的な than the contraceptive pill is at 妨げるing pregnancy).?

Sold in the US under the brand 指名する Truvada, the pill consists of two 薬/医学s (tenofovir dosproxil fumarate and emtricitabine). Those 薬/医学s can 開始する an 即座の attack on any trace of HIV that enters the person's bloodstream, before it is able to spread throughout the 団体/死体.?

It has proven incredibly 効果的な.?But not enough people take it.?

The CDC says around 1.1 million Americans are at-危険 of HIV and should be taking PrEP.?

現在/一般に, around 200,000?do take it.

There is another similarity with the contraceptive pill (and IUD, implant, (犯罪の)一味, patch -what have you): there is stigma around using PrEP.?

It has been branded the 'promiscuity pill,' even by some doctors and health 公式の/役人s who 空気/公表する 恐れるs that it will lead to more condomless sex.?

ーに関して/ーの点でs of STD 予防, the heated 審議 is a difficult one. A condom is the only thing that 保護するs against STDs like chlamydia, gonorrhea and syphilis.?

If more people see the pill, IUDs, PrEP etc as a 交替/補充 for condoms , there could be a 減少(する) in condom use, which 脅すs a rise in other STDs. Indeed: PrEP has been partly 非難するd for a rise in syphilis 率s の中で gay men in the US. (率s have also risen の中で 異性愛の women and newborns).? ??

But 支持する/優勝者ing condoms (or abstinence) is unrealistic, health 公式の/役人s 警告する.

Chris Beyrer, MD, former 長,指導者 of the International エイズ Society, says we need to 受託する that people do have, want and enjoy unprotected sex - whether it's for the feeling, or by 事故.

A stronger approach to 妨げるing HIV 伝達/伝染 would be to get more people on PrEP, 徹底的に 上げる STI 審査, and put all our 成果/努力s into making healthcare, 実験(する)ing, doctors and (警察などへの)密告,告訴(状) more accessible.?

'Condom use 率s have never been that 広大な/多数の/重要な,' Dr Beyrer, MD, told DailyMail.com. 'And the next 世代 of younger people now are using them いっそう少なく than before.?

'People have to be real and not stigmatizing about the fact.

'In a U=U 時代 they are not going to use condoms. That 要求するs honest discussion, and more 正規の/正選手 STI 審査.'?

As Demetre Daskalakis, 副 commissioner of HIV/エイズ at New York City's Department of Health, told STAT in an interview last year: 'We still have to sell this to [clinicians] who are like, "Why would I be 申し込む/申し出ing people PrEP, if it's going to encourage them to have condomless sex?"?

'And our answer tends to be: "They're already having condomless sex and this 妨げるs HIV."'??

3. 焦点(を合わせる) on the South?

New York City has had been held up as the poster child for success in 上げるing the use of PrEP and cutting 率s of new HIV 診断するs.?

A 報告(する)/憶測 in 2017?showed 2,279 new 診断するs were 記録,記録的な/記録するd in 2016 - a nine パーセント 減少(する) from the 2,493 new 事例/患者s in 2015.? The biggest 減少(する) in 感染s was seen の中で gay men, dropping 15 パーセント from 1,450 new 事例/患者s in 2015 to 1,236 new 事例/患者s a year later.

Since 2007, PrEP use in New York City has 増加するd ten-倍の - a faster uptake than anywhere else. ?

国家的に, 率s of PrEP use have gone up, too - rising 30 パーセント from 2016 to 2017.

But the 進歩 is lopsided.

The South accounts for half of new HIV 診断するs, concentrated in 46 郡s (out of America's 3,000 郡s).?

And yet, Southerners account for only 30 パーセント of PrEP 使用者s, によれば AIDSVu.??

There are many factors that 運動 HIV 危険 up in the South.

New HIV diagnoses: This map (of 2015 stats) shows how concentrated the HIV epidemic is. The South accounts for half of new HIV diagnoses, concentrated in 46 counties (out of America's 3,000 counties)

New HIV 診断するs: This 地図/計画する (of 2015 stats) shows how concentrated the HIV 疫病/流行性の is. The South accounts for half of new HIV 診断するs, concentrated in 46 郡s (out of America's 3,000 郡s)

Expanding Medicaid, particularly in southern states with high HIV rates and low PrEP use, could be a game changer?

拡大するing Medicaid, 特に in southern 明言する/公表するs with high HIV 率s and low PrEP use, could be a game changer?

THE ISSUES WE FACE IN THE SOUTH: AS TOLD BY AN ALABAMA STD CLINICIAN?

Edward W Hook III, MD, a professor at the University of Alabama, has worked in an STD clinic in Birmingham, Alabama for 27 years.?

He told DailyMail.com the 障壁s he sees to ending HIV 伝達/伝染s in the 地域.?

1. 接近 to care

'It's important to realize it's the South East US that didn't embrace Medicaid 拡大 and 財政上の support for public health 機関s.?

'Things are probably more challenging here in the Southeastern 部隊d 明言する/公表するs than other parts of the nation [ーに関して/ーの点でs of STDs].?

'The ability to have public health 基金s 同様に as 保険 is 批判的な.'

2. Stigma: People are afraid to even 収容する/認める they have male sex partners

'There are general levels of stigma.?

'Men who have male 性の partners -特に 少数,小数派s - are いっそう少なく likely to 公表する/暴露する the fact that to others.?

'That inhibits the ability to take care of them and their 性の health care.'?

3. Sex ed: Teaching abstinence-only doesn't work

'I do think that the US probably is a bit more uptight about sex and sexuality [compared to other places like Europe].?

'Our 問題/発行するs regarding teaching 性の health to young people are いっそう少なく than optimal.

'There are a number of solid 科学の 熟考する/考慮するs to show that abstinence-only teaching doesn't 減ずる sexually-transmitted 感染s.?

'In fact people who are in abstinence-only settings are いっそう少なく likely to 可決する・採択する 保護の 性の activity.'

4. 非難する-game language

'I don't engage in the 非難する game.??

'I'm afraid it's pretty ありふれた 負かす/撃墜する here and it's 明白に not 生産力のある.?

'The entire 20th century that was the approach [to STD 予防 in general] - tha t we were doing something wrong.?

'Most sexually-transmitted 病気s are transmitted by people who don’t know that they are 感染させるd and they are not doing it?on 目的.

'Here at our 医療の school we are trying to get people to change their vocabulary.'?

宣伝

The 地域 is home to high 率s of poverty, income 不平等, poor health and いっそう少なく 詳細(に述べる)d 性の education than other parts of the US.

Health 保険 ニュース報道 is lowest in Texas, Oklahoma, Georgia and Florida. In each, より小数の than 19 パーセント of people have ニュース報道.

What's more, it's the Bible Belt - a 地域 where all sexuality, 特に homosexuality, has 歴史的に been stigmatized.?

A 目印 熟考する/考慮する by the CDC in 2002 設立する that stigma against people at-危険 of HIV - おもに men who have sex with men and transgender women - makes people いっそう少なく likely to 捜し出す care.??

4. 焦点(を合わせる) on young people, 特に 少数,小数派s

Late last year, new CDC 人物/姿/数字s 明らかにする/漏らすd new HIV 診断するs are rising の中で young people, as 率s 急落する or 持つ/拘留する 安定した in older 全住民s.?

The 報告(する)/憶測, based on data collected between 2008 and 2016, 示すd a growing generational divide.?

In that time, the 率 of new 感染s for under 30s was four times the 率 for gay men 老年の 30 to 50, who grew up in the harrowing エイズ 疫病/流行性の of the 80s and 90s. The 率 for over 50s remained 不変の.??

The はっきりした rises were seen in African American and Latino men, 特に in the South, who the CDC 警告するs are under-served with 資源s and (警察などへの)密告,告訴(状).?

'We have known for at least a 10年間 that this is a very concentrated 疫病/流行性の, and that we have very powerful 予防 techniques. And still, this is 2016 data showi ng a three パーセント a year 増加する,'?Dr Beyrer told DailyMail.com, 反映するing on the data.?

'That's a?very high 感染 率 by any 基準. That's higher than communities you think about like Uganda. Yes, if you look at the 全住民 level it's low, but this is a very concentrated 疫病/流行性の, and in this group 率s are going up not 負かす/撃墜する.'

Dr Anthony Fauci, 長,率いる of the HIV/エイズ 分割 at the 国家の 学校/設けるs of Health, told DailyMail.com when the 報告(する)/憶測 was published in September: 'It's just going in the wrong direction.?I'm as 乱すd as anybody to see an 増加する in any パーセント at this 行う/開催する/段階 of where we are in this pandemic.

'And it's very 乱すing that it's 特に young men who have sex with men.

'If we are going to 達成する the goal which we are all 努力する/競うing for - turning it around to say we no longer have an 疫病/流行性の; we have 支配(する)/統制する - then we need to take this 本気で. You're not going to have that if the 支配的な group, young men and in particular African American young men is seeing an 増加する like this. It's going to put you 支援する, even when the other groups do better.'?

接近 to care, stigma, and 基金ing are (疑いを)晴らす 障壁s to young people as they try to get to 支配するs with how to 独立して navigate America's 混乱させるing healthcare system.

But there are also 関心s of complacency, によれば a 最近の 報告(する)/憶測 by the International エイズ Society.???

In July 2018, the society published a 報告(する)/憶測 警告 that the excitement about かもしれない reaching an end to the 疫病/流行性の 'has bred a dangerous complacency and may have 急いでd the 弱めるing of 全世界の 解決する to 戦闘 HIV.'

The CDC 人物/姿/数字s months later - showing a rise in 率s の中で young people, who do not have memory of the エイズ 疫病/流行性の's 荒廃 - 追加するd 負わせる to those 関心s.?

People who 港/避難所't lived through 外傷/ショック do not build up an armor for it the same way.??

'This is why we worry about the 問題/発行する of complacency,' said Dr Beyrer, who co-authored the July 報告(する)/憶測.

In the last few years, he 警告するs, 'people have been embracing this language of "getting to 無". In 影響, that we would have 無 new 診断するs.'

That, he says, puts everyone at 緩和する. And 緩和する is not a 明言する/公表する we can embrace just yet.

'When you have three パーセント a year new 感染s in a young group of people, you're not 長,率いるing に向かって 無.'

5. Broaden 接近 to care

PrEP costs $1,500 a month (a 人物/姿/数字 that's rising) without 保険 or 補助金s. With 保険, it is 大部分は 解放する/自由な aside from co-支払う/賃金s.?

拡大するing Medicaid, 特に in southern 明言する/公表するs with high HIV 率s and low PrEP use, could be a game changer.

For those without 保険, 確かな parts of the US 供給する 基金ing - 含むing New York City - and Gilead, which makes Truvada, runs an 前進するing 接近 Co-支払う/賃金 Program.

Across the US, low-income people without 保険 can be 補助金を支給するd for ART thanks to the Ryan White program, the 連邦の 認める that 供給するs HIV/エイズ 治療 for low-income Americans. However, PrEP is for people who do not have HIV. For them, there is no 明確な/細部 マリファナ of money.?

Some of this could be helped by more 基金ing to the 中心s for 病気 支配(する)/統制する and 予防, the 連邦の 団体/死体 仕事d with rolling out 病気 予防 道具s.

We have plenty of 道具s and 研究, thanks in part to 連邦の 基金ing t o the 国家の 学校/設けるs of Health.?

Funneling 基金s to the zip codes with the highest 率s of HIV 伝達/伝染 - to roll out both 医薬 and 認識/意識性 - would make an 衝撃.

But as with any 医薬: 基金ing isn't the only 障害 to rolling it out.??

It's one thing making the 医薬 利用できる, it's another thing getting people to retrieve it.??

Everywhere except for New York City 要求するs a follow-up 任命 to get PrEP (after a 消極的な 実験(する) result) or ART (after a 肯定的な).

Health 公式の/役人s 警告する that is a 障壁 to care.?

The more people are 申し込む/申し出d these 決定的な 薬/医学s on the 位置/汚点/見つけ出す, the more people will be 保護するd from the ウイルス or unable to 送信する/伝染させる it.????

6. Getting people to use that care: Build 信用 with at-危険 groups

'医療の 不信 is real,' Dr Beyrer, who is also a professor at the Johns Hopkins Bloomberg School of Public Health, told DailyMail.com.?

'We don't 熟考する/考慮する it but we did 査定する/(税金などを)課す it [in a 最近の 熟考する/考慮する] の中で [150] men who were living in HIV, and we were not 極端に surprised.?

'Just from what 関係者s and providers were telling us, it's very real and it appears also an important 障壁 to PrEP.'

迫害するd 全住民s recoil from their 攻撃者s.

This graph from the CDC in 2014 shows the rate of new HIV diagnoses in the South, broken down into demographic categories. The highest rate was among black men who have sex with men, and the lowest was black female injection drug users

This graph from the CDC in 2014 shows the 率 of new HIV 診断するs in the South, broken 負かす/撃墜する into demographic 部類s. The highest 率 was の中で 黒人/ボイコット men who have sex with men, and the lowest was 黒人/ボイコット 女性(の) 注射 麻薬 使用者s

The Tuskegee 実験 is an example of 医療の 不信's 遺産/遺物, new 研究 示唆するs.?Hundreds of 黒人/ボイコット men with syphilis in Tuskegee, Alabama entered a 治療 中心 between 1932 and 1972. They were given placebos instead of 治療 so doctors could see how their 病気 developed.

In the years after the スキャンダル was exposed, the health of 黒人/ボイコット men 拒絶する/低下するd across the US.??

Marianne Wanamaker, an associate professor of 経済的なs at the University of Tennessee who has spent years 研究ing the 実験, says we cannot definitively 証明する the link, but the correlation is striking.??

After the Tuskegee スキャンダル broke, the 率 of 黒人/ボイコット men 定期的に visiting a doctor 急落するd. So, too, di d 黒人/ボイコット men's life 見込み - a 下落する we're still struggling to 回復する from.?

Her co-研究員 Marcella Alsan at Stanford took it a step その上の, showing that 黒人/ボイコット men are more likely to follow a doctor's advice if their doctor is 黒人/ボイコット.?

We can't say definitively that Tuskegee led to this - Tuskegee, Wanamaker points out, could 簡単に symbolize a broader sense of 不信 with さまざまな roots. But it's there.?

In the absence of a (疑いを)晴らす link, she and Alsan have turned to looking at anti-エイズ (選挙などの)運動をするs, which did seem to have an 衝撃.?

Slowly, HIV 実験(する)ing 率s are going up - a 調印する, Wanamaker says, that 'somehow we overcame the 不信.'???

Clinicians 警告する the 衝撃 is 女性 than it should have been, 大部分は because there was so much 抵抗 from leaders to take the 疫病/流行性の 本気で in the 80s.?

That left a 示す.?

The community was obliterated by a 疫病/悩ます in 最近の memory, neglected by the powerful, and the 支配する of abusive hate (選挙などの)運動をするs.?

As thousands died, the community learned that they could not 信用 the (警察などへの)密告,告訴(状) coming through 公式の/役人 channels.

Out of that fury was born 行為/法令/行動する Up, Dallas 買い手's Club, and more - groups that have since been 称讃するd for leap-frogging 公式の/役人s and 分配するing 薬/医学s and (警察などへの)密告,告訴(状) themselves, while getting の上に the 最高の,を越す (米)棚上げする/(英)提議するs with health 長,指導者s to 影響する/感情 change and form 政策.

By the time ART was made 利用できる in 1995, more than 300,000 people had died of エイズ and it was the 主要な 原因(となる) of death for people 老年の 25 to 44 in the 部隊d 明言する/公表するs.?

Speaking to people most at-危険 of 契約ing HIV (men who have sex with men), Dr Beyrer sees a 欠如(する) of (疑いを)晴らす underst anding about what care 伴う/関わるs, what 予防 entails, and a 欠如(する) of 信用 in doctors.??

Many feel nervous about what to 推定する/予想する, and 気が進まない to 株 the 詳細(に述べる)s they need to 株.?

Dr Edward Hook III, MD, a clinician at an STD clinic in Birmingham, Alabama and a professor at the University of Alabama, 観察するs the same.?

'There is a general stigma,' he told DailyMail.com

'Men who have male 性の partners -特に 少数,小数派s - are いっそう少なく likely to 公表する/暴露する the fact that to others.?

'That inhibits the ability to take care of them and their 性の health care.'???

Cameron Kinker, of the 予防 接近 (選挙などの)運動をする (PAC), which spearheaded the now globally 認めるd (選挙などの)運動をする to 認める that U=U, says stigma needs to be 認めるd as a 固める/コンクリート 障壁 to care.

'If a person is 気が進まない to 直面する the reality that they may 実験(する) 肯定的な or 恐れる that they may 直面する 裁判/判断 from health care providers, they are much いっそう少なく likely to get 実験(する)d,' Kinker told DailyMail.com.?

'Encouraging 正規の/正選手 実験(する)ing and 標準的にする/正常にするing it as a 正規の/正選手 part of 医療の check-ups would go a long way in fighting 伝達/伝染. Stigmatizing language only serves to 増強する this 恐れる and 悪化させるs STI 伝達/伝染 率s.'

The U=U (選挙などの)運動をする has won legions of 支持者s - 含むing the 長,率いるs of the CDC and NIH - as a way to 戦闘 stigma on a 国家の and international level.?

Since 2015, nearly 100 countries have put the phrase into their 公式の/役人 literature in a 企て,努力,提案 to 動機づける people with HIV to get on 医薬 and stick with it so their v irus can be undetectable/untransmittable.?

In a clinic setting, Dr Hook said he has 設立する 患者s incredibly responsive to just a slight 転換 in language - telling 患者s he is happy to be able to give a diagnosis, 関わりなく the 結果, and 存在 understanding of their lifestyles.?

'I don't engage in the 非難する game,' he told DailyMail.com.??

'I'm afraid it's pretty ありふれた 負かす/撃墜する here and it's 明白に not 生産力のある.?

'The entire 20th century that was the approach [to STD 予防 in general] - that we were doing something wrong.?

'Most sexually-transmitted 病気s are transmitted by people who don’t know that they are 感染させるd and they are not doing it?on 目的.

'Here at our 医療の school we are trying to get people to change their vocabulary.'?

A CURE IS STILL OUT OF REACH - BUT WE ARE GETTING CLOSER

Dr Robert Siliciano, a professor of 薬/医学 at Johns Hopkins, was part of the team that discovered HIV's latent 独房s in 1995 - a 調印する that a cure would be incredibly hard to arrive at.

It was incredibly demoralizing to discover, he says, the same year that viral-抑えるing anti-retroviral therapy was discovered.

ART, which became 利用できる in 1996, 示すd a turning point after a 10年間 of agony, more than 300,000 deaths, more than 500,000 感染s, and incredibly 延期するd 返答s from 公式の/役人s to 答える/応じる to the 疫病/流行性の.

The 発見 of the latent 貯蔵所s 鈍らせるd hopes that ART could 示す a 最終的な end.

Twenty-three years on, he is still 押し進めるing for ways to kill the ぐずぐず残る, latent 独房s and reach a '機能の' cure.

THE BERLIN PATIENT: THE ONLY PERSON EVER CURED OF HIV - AND WHY IT NEVER WORKED AGAIN?

Timothy Brown, 'the Berlin patient' who was cured of HIV in Berlin in 2007

Timothy Brown, 'the Berlin 患者' who was cured of HIV in Berlin in 2007

The only person ever cured of HIV is an American man called Timothy Brown, 広範囲にわたって known as 'the Berlin 患者' because he was cured in Berlin in 2007.

Brown already had HIV when he was 診断するd with 白血病, a 病気 of the bone 骨髄 which can be 扱う/治療するd with a bone 骨髄 移植(する).?

Bone 骨髄 移植(する)s are usually the last 訴える手段/行楽地 because there is a 重要な 危険 of death, by 誘発する/引き起こすing a war between the person's 初めの 免疫の system and the new implanted one.?

But Brown didn't have many other 選択s. Once he agreed, his doctor 示唆するd trying to select a 寄贈者 who had 遺伝子s known to be 抵抗力のある to HIV. At the time it was more of an 試みる/企てる to 保護する him, rather than cure him.?

Not only did Brown 生き残る the 操作/手術, and 生き残る 解放する/自由な of 白血病, he also had no trace of the human immunodeficiency ウイルス.?

The news 激しく揺するd the 医療の community, with 憶測 that this could be the end of HIV/エイズ.?

However, 試みる/企てるs to replicate it were 破滅的な.?

A 報告(する)/憶測 published by the New England 定期刊行物 of 薬/医学 in 2014 述べるd six 試みる/企てるs to 扱う/治療する HIV 患者s with a 茎・取り除く 独房 寄付, but 非,不,無 lived longer than a year.?

宣伝

The 計画(する) is to work out how to bring latent HIV 独房s out of hiding - shock them into an active 明言する/公表する.?

Then, when they are active, kill them.

It would not end HIV, but it would put 患者s into a 明言する/公表する where they would be in remission - they could stop taking 麻薬s and would not relapse. They may still have some viral 独房s but not enough to 送信する/伝染させる, and not enough to 害(を与える) them. The 独房s would be so 攻撃を受けやすい to attack that a relapse wouldn't take off.?

Essentially, the 免疫の system would be able to 自然に 支配(する)/統制する the ウイルス - as is the 事例/患者 for a small 割合 of people in the world.??

Most of us are known as 'progressors' - if we become 感染させるd with HIV, and we don't take 医薬 to 抑える the ウイルス, our T 独房s 徐々に 使い果たす. 結局, there are so few T 独房s that the 病気 develops into エイズ.??

Then you have 'エリート 監査役s' who account for about one パーセント of the 全世界の 全住民. They have the strongest natural 鎮圧 of HIV. Without 医薬, their T 独房 count 減少(する)s but at a much slower 率, and rarely 進歩s to エイズ.?

Another, larger 派閥 of the 全世界の 全住民 are 'viremic 監査役s', who have a detectable level of the ウイルス but without 医薬, their 病気 進歩s at a much slower 率 than most.??

The 目的(とする), Dr Siliciano says, is to work out a way to make us all エリート 監査役s.?

That would be a cure, of sorts.?

It is different to the Berlin 患者 (see box), whose ウイルス was 完全に wiped out in 2007 by a bone 骨髄 移植(する) to 扱う/治療する 白血病 (試みる/企てるs to replicate that in other people with HIV failed with 致命的な consequences). That would be a 'sterilizing cure' and Dr Siliciano is doubtful we can see th at on the horizon.?

But Brown's cure gave 研究員s like Dr Siliciano - and others, 特に in the 開拓するing teams at UNC and UCSF - 新たにするd 動機づけ that this wasn't a lost 原因(となる).?

'We could see, this 現実に can happen, even though the 機械装置 was different,' Dr Siliciano told DailyMail.com.?

In 2008, there was a 押し進める to try.?

'For a long time it was just considered a hopeless problem and we were discouraged from using the "cure" word because you don't want to give 患者s 誤った hope that this could be possible.'

And now? 研究 has にわか景気d. Findings by Dr Siliciano, David Margolis at UNC and Steve Deeks at UCSF in the 早期に 2010s 押し進めるd the NIH to 充てる energy to the 原因(となる), 開始する,打ち上げるing big collaborative groups and federally-基金d 事業/計画(する)s.?

In September, Dr Margolis's team 証明するd an HIV immunotherapy 麻薬 - that would 成し遂げる the 'shock and kill' approach - was 安全な in a 段階 1 裁判,公判.?

'We think that we will be able to replicate the results of the Berlin 患者 [the only person ever cured of HIV], but that will take a while, on a step-by-step trajectory,' Dr Margolis, co-上級の author of the paper, told DailyMail.com at the time.?

And last week, Dr Siliciano published a paper that 設立する, for the first time, how to 正確に count the latent HIV 独房s in a person's 貯蔵所 -?meaning that, as we start trying the shock-and-kill method, we can 跡をつける how we're doing, and truly understand a person's total HIV count.?

These are all small steps, but 重要な 軽く押す/注意を引くs に向かって the ultimate goal.??

'It's not hopeless,' Dr Siliciano said.

'We know what the 的 is 基本的に, but the difficulty is how to turn on the latent ウイルス in a way that' s 安全な for the 患者. And that's a really difficult thing.

'We need to at least try to do it.'??

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