New £10-000-a-year arthritis pill that can end the hell of stiff 共同のs could bring 救済 to more than 400,000 Britons
- Some 400,000 Britons を煩う rheumatoid arthritis and are in 広大な／多数の／重要な 苦痛
- Many young people 苦しむing with the 条件 can be left using 車椅子s?
- 現在の 治療s are only able to soothe 苦痛 or 鈍らせる the inflammation?
- A new tablet, Rinvoq could see symptoms disappear in 40pc of 患者s??
NHS 患者s with rheumatoid arthritis are to 利益 from a 打開 麻薬 that 緩和するs the agonising 苦痛 in 共同のs.
The 条件 影響する／感情s 400,000 Britons ? many of them young adults ? who can be left 車椅子-bound 予定 to the 苦痛 and energy-sapping exhaustion it 原因（となる）s.
現在の 治療s are able to soothe 苦痛 and 鈍らせる inflammation but they rarely get rid of symptoms altogether. Some also need to be 注入するd straight into the bloodstream, which has to be carried out by a healthcare professional.
The new 薬／医学, Rinvoq, is a once-daily tablet, making it an easier 選択. 臨床の 裁判，公判s have also 明らかにする／漏らすd that it is remarkably 効果的な, with up to 40 per cent of 使用者s seeing their symptoms disappear. It also 作品 in those most 厳しく 攻撃する，衝突する by the 病気.
A new 薬／医学 called Rinvoq could see symptoms disappear in 40 per cent of the 400,000 患者s in Britain who are 影響する／感情d by rheumatoid arthritis. It could also 緩和する the symptoms of those with the most serious form of 条件
Rheumatoid arthritis occurs when the i mmune system turns on the 団体／死体 and attacks 独房s that line the 共同のs. Why this happens is not （疑いを）晴らす, but some 証拠 示唆するs even a minor 感染 can ‘trip’ the 免疫の system into going haywire. It often 攻撃する，衝突するs 患者s in their teens or 20s, and there appears to be a genetic element, with the 病気 running in families. Women are also more likely to get it.
にもかかわらず Rinvoq’s £10,000-a-year price tag, it has been given the green light in England by the 麻薬 監視者, the 国家の 学校／設ける for Health and Care Excellence (NICE), and will be 申し込む／申し出d to 患者s who have not 設立する 救済 from other 治療s. 専門家s have あられ／賞賛するd the 判決，裁定 as a major 打開, and one of the first 患者s to 利益, who once relied on a walking stick, says that thanks to the pills he’s now ‘jumping out of bed’.
‘This is very welcome news,’ says Professor Chris Edwards, 顧問 rheumatologist at University Hospital Southampton NHS 創立／基礎 信用. ‘Rinvoq is able to induce 病気 remission, even when the 条件 has not 答える／応じるd to previous 治療s.’
Rinvoq, also known as upadacitinib, belongs to a new class of tablets known as JAK inhibitors, which are transforming 治療s.
The 麻薬s work by 封鎖するing the 影響s of enzymes known as janus kinase that help to 活動させる／戦時編成する the 免疫の 返答 when the 団体／死体 is under attack from 侵略するing organisms, such as ウイルスs or bacteria. By 封鎖するing these enzymes, the 麻薬s stop the 免疫の system from destroying healthy 共同の tissue.
A new £10,000-a-year 麻薬 Rinvoq, pictured, could help some of the 400,000 people in Britain who 苦しむ rheumatoid arthritis?
Rinvoq’s 是認 by NICE follows 類似の 判決，裁定s for two other JAK inhibitors, tofacitinib and baricitinib ? also daily tablets.
JAK inhibitors are also 存在 used to 取り組む other autoimmune disorders, such as Crohn’s 病気 and 厳しい psoriasis, and are 存在 trialled as a 治療（薬） for ankylosing spondylitis ? a 手足を不自由にする／（物事を）損なうing spinal 条件 where the bones in the spine can fuse together.
Even baldness is a possible 的, as 熟考する／考慮するs have 設立する the 麻薬s help 誘発する／引き起こす new hair growth.?
Prof Edwards says although there have been no 熟考する／考慮するs 直接／まっすぐに comparing the 有効性 of the 麻薬s there’s some suggestion Rinvoq may be 特に 効果的な. ‘It 行為／法令／行動するs on JAK pathways in a わずかに different way,’ he says. ‘This could 影響する／感情 how 井戸／弁護士席 it 作品. But the best results are 一般に seen when JAK inhibitors are given と一緒に an old 麻薬 for rheumatoid arthritis, called methotrexate.?
Methotrexate helps by 抑えるing the 免疫の system to 減ずる 共同の 損失, but using it can 本気で 損失 the 肝臓.
Clare Jacklin, of the 国家の Rheumatoid Arthritis Society, says doctors need as many 武器s as they can 召集（する） again st the life-changing 病気
Clare Jacklin, of the 国家の Rheumatoid Arthritis Society, says doctors need as many 武器s as they can 召集（する） against the life-changing 病気.
She 追加するs: ‘It’s a コンビナート／複合体 条件 which 要求するs different 医薬s. This is good news.’
Neil Feather, 55, was one of the first 患者s to be 扱う／治療するd with Rinvoq as part of a 臨床の 裁判，公判 at 物陰／風下d Teaching Hospitals NHS 信用. The father-of-one, an IT services 経営者／支配人 from Wakefield, West Yorkshire, had noticed that his 共同のs were getting stiff and sore about six years ago.
He says: ‘I would get out of bed and it would take 30 minutes before I could get moving ? everything was stiff and painful. After sitting at a desk for a few hours, my 脚s would give way when I stood up. I had a walking stick to get around.’
血 実験（する）s by his GP 確認するd that Neil was in the 早期に 行う／開催する／段階s of rheumatoid arthritis ? but he was in luck as the hospital was looking for 患者s to try Rinvoq.
Neil 調印するd up. He 追加するs: ‘I felt better within a couple of weeks, and I was jumping out of bed rather than struggling to get moving. After six months on the 麻薬, I had no symptoms at all. The 苦痛 and swelling had disappeared.’
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