`Game-changer´ 実験（する） 位置／汚点／見つけ出すs 調印するs of モーター neurone 病気 before symptoms - 熟考する／考慮する
A 実験（する） that 位置／汚点／見つけ出すs 調印するs of モーター neurone 病気 before symptoms appear has been あられ／賞賛するd a “game changer” by scientists developing it.
The 道具, known as TDP-43 aptamer, is able to （悪事，秘密などを）発見する 損失d 独房 proteins in brain tissue 見本s.
研究員s said these proteins are 指示する人（物）s, or biomarkers, of MND that can be spotted before 独房s begin to 機能不全 and symptoms start to appear.
They said that （悪事，秘密などを）発見するing the 条件 at its earliest 行う／開催する／段階s opened the door for more 効果的な 治療s.
Dr Holly Spence, from the University of Aberdeen, said: “Our findings have 関わりあい／含蓄s for 早期に diagnostics and 介入 事前の to symptom onset in MND.
“With better ability to （悪事，秘密などを）発見する 病気, we might be able to 診断する people with MND earlier, when 治療力のある 麻薬s might be much more 効果的な.”
MND 影響する／感情s around 5,000 people in the UK.
There’s no cure for the 条件, but 治療s can help 減ずる its 衝撃 on a person’s daily life.
It is 原因（となる）d by a build-up of 確かな proteins in the brain that clump together, 原因（となる）ing the 独房s to 徐々に stop working.
Symptoms 含む impaired movement, thinking and breathing, which より悪くするs over time.
The “aptamer” lab 実験（する） 作品 by identifying 異常な protein clumps in a brain tissue 見本 taken from a 患者 during 生体検査.
The 研究員s said their 実験（する） could 選ぶ up 指示する人（物）s of MND earlier and with more sensitivity than methods 現在／一般に used.
Dr Jenna Gregory, from the University of Aberdeen, said: “This 道具 ‘的s’ the 病気 protein and 許すs us to see where 有毒な clumps are building up in the 団体／死体.
“It can do this for much lower 量s of 病気 proteins, and with greater 正確 than ever before.
“This could be a game changer for MND 研究, diagnostics and 治療.”
The 研究 was 基金d by 的 ALS and is published in the 定期刊行物 Acta Neuropathologica.
Commenting on the 研究, Dr Brian Dickie, director of 研究 at the モーター Neurone 病気 協会, said: “It often takes a year from the first onset of symptoms to receiving a diagnosis of MND.
“This innovative 研究 into the 早期に 細胞の changes occurring in MND 申し込む／申し出s exciting 可能性のある for the 開発 of new 実験（する）s to help 減ずる diagnostic 延期する.
“As 治療 does not begin until the 病気 is 診断するd, earlier 介入 will hopefully also mean that 治療s are more 効果的な.”
Jessica 物陰／風下, director of 研究 at the My 指名する’5 Doddie 創立／基礎 ? 始める，決める up by the late Scottish rugby union player Doddie Weir ? 追加するd: “モーター neurone 病気 is a 破滅的な 条件 for which there are 現在／一般に no 効果的な 治療s and long 延期するs in diagnosis.
“予定 to 進歩s in 研究, many 可能性のある 治療s are 現在／一般に 存在 調査するd in the lab and in 臨床の 裁判，公判s.
“However, we now need 強健な biomarkers of 病気 to support the evaluation of these 治療s and to 速度(を上げる） up diagnosis, so that 治療s can be started earlier in 病気 progression.
“This exciting new 科学（工学）技術 持つ／拘留するs 約束 to do just that.”
Jill Douglas, 長，指導者 (n)役員／(a)執行力のある of the My 指名する´5 Doddie charity said that Doddie Weir´s 遺産／遺物 "goes on" (PA)
Weir was “horrified at the 欠如（する） of hope” given to people 診断するd with MND, his friend said.
Jill Douglas, 長，指導者 (n)役員／(a)執行力のある of the My 指名する’5 Doddie charity, said that the organisation was “慎重に excited” by the 開発, but told Sky News: “There’s a 欠如（する） of hope for people within the MND community and so there is a 傾向 いつかs to be very excited about news like this ? we have to approach it with 警告を与える until we better understand what its 関わりあい／含蓄s might be.”
She 追加するd: “There needs to be a real 一致した 成果／努力 to do something for this 病気 and we feel as though we are on the cusp of a 打開 for 現れるing 治療s. We just need to keep the foot on the pedal.
“When Doddie was 診断するd, he was horrified at the 欠如（する） of hope afforded people who are given this 残虐な diagnosis that there are no 治療s ? the one 麻薬 that has been 定める／命ずるd 追加するs two or three months to your life 見込み.
“So he 手配中の，お尋ね者 to really make a difference, to 向こうずね a light on the 病気, which I think he did, really raising the profile.
“He was an incredible character, Doddie, and his 遺産／遺物 goes on. He didn’t want us to stop. He said, ‘Keep going, we need to 向こうずね a light on this 病気, we need to help people who are given this awful diagnosis and one day work に向かって 効果的な 治療s and a cure’.”
She 追加するd: “You’ll have seen some of the people who’ve been struck by this awful 病気, my 広大な／多数の／重要な friend, Doddie ? to see a 巨大（な） of a man like that felled by it was was really hard for everybody.
“And also we see 略奪する Burrow and how bravely he’s taking on MND and with the help of his 広大な／多数の／重要な friend, Kevin Sinfield.”
