Hydroxychloroquine does NOT 扱う／治療する Covid-19: Biggest 熟考する／考慮する into the Donald Trump-支援するd anti-malaria 麻薬 is ended with '即座の 影響' after 研究員s 設立する it made no difference

  • Oxford University scientists pulled the 麻薬 from the RECOVERY 裁判，公判 today
  • Results showed it had no 利益 on NHS 患者s hospitalised with the ウイルス
  • Scientists running the 裁判，公判 has 勧めるd doctors around the world to stop using it
  • Here’s how to help people 衝撃d by Covid-19

By Connor Boyd Health Reporter For Mailonline

Published: | Updated:

Hydroxychloroquine does not 扱う／治療する coronavirus, によれば the world's biggest 裁判，公判 of the anti-malaria 麻薬 支援するd by US 大統領 Donald Trump.

Oxford University scientists pulled the 議論の的になる 麻薬 from the RECOVERY 裁判，公判 today after results showed it had no 利益 on 患者s hospitalised with the ウイルス.

A ４半期/4分の1 of NHS 患者s given hydroxychloroquine died from Covid-19, compared to 23.5 per cent who were not 定める／命ずるd the 麻薬.

The scientists running the 裁判，公判, which has 新採用するd more than 1,500 患者s from around 170 UK hospitals, said the results were 'pretty 説得力のある', 追加するing: 'This isn't a 治療 that 作品.'

Professor ツバメ Landray, lead author of the 熟考する／考慮する, 追加するd: 'If you're 認める to hospital with Covid ? you, your mother or anyone else - hydroxychloroquine is not the 権利 治療. It doesn't work.'

He called for doctors around the world to stop using the 麻薬, which can 原因（となる） a slew of 汚い 味方する 影響s 含むing heart arrhythmias, 頭痛s and vomiting.?

But Professor Landray said the results do not やむを得ず mean the tablets cannot 妨げる people from catching Covid-19 in the first place, which several 熟考する／考慮するs are still 調査／捜査するing.?

早期に results on hydroxychloroquine from the RECOVERY 裁判，公判 were not supposed to 解放（する）d until July. But the 熟考する／考慮する's 長，指導者 捜査官／調査官s said they felt compelled to 解放（する） the data and 始める，決める the 記録，記録的な／記録する straight on the 麻薬, which has been at the centre of furious 審議.?

US 大統領 Donald Trump あられ／賞賛するd it as a wonder 麻薬 at the start of the 危機 and 認める to taking it himself to 区 off the 感染, while countries like 中国 and India 定期的に 定める／命ずる it to Covid-19 患者s.?

It comes after 医療の 定期刊行物 The Lancet last night 撤回するd a 議論の的になる 熟考する／考慮する that 設立する hydroxychloroquine raised the 危険 of death in Covid 患者s, which led to 裁判，公判s 存在 停止（させる）d around the world.???

Hydroxychloroquine does not treat coronavirus, the largest study into the drug has found

Hydroxychloroquine does not 扱う／治療する coronavirus, the largest 熟考する／考慮する into the 麻薬 has 設立する?

A total of 1,542 患者s were 無作為に given hydroxychloroquine and compared with 3,132 患者s randomised to receive 基準 care in the Oxford 裁判，公判.

After 28 days, 25.7 per cent of 患者s taking the malaria tablets passed away from the ウイルス compared to 23.5 per cent who were not given the 薬／医学.

With tens of thousands of Covid 患者s around the globe still 存在 定める／命ずるd the 麻薬, today's results could have a knock-on 影響 around the globe.

Professor Martin Landray, deputy chief investigator of the Recovery trial, said the results on hydroxychloroquine were ‘pretty compelling, this is not a treatment that works'

Professor ツバメ Landray, 副 長，指導者 捜査官／調査官 of the 回復 裁判，公判, said the results on hydroxychloroquine were 'pretty 説得力のある, this is not a 治療 that 作品'

Oxford University's Professor Peter Horby, who is also 長，率いるing the 裁判，公判, said he phoned the World Health Organization (世界保健機構) this morning to 株 the findings.

He has advised the 全世界の health 団体／死体 to 減少（する） the 麻薬 from its SOLIDARITY 裁判，公判 and 焦点（を合わせる） 成果／努力s on other 約束ing 薬／医学s.

Professor said he 推定する／予想するd 世界保健機構 to '再考する' trialling the 麻薬 on the 支援する of the findings.?

He 追加するd: 'Hydroxychloroquine and chloroquine have received a lot of attention and have been used very 広範囲にわたって to 扱う／治療する Covid 患者s にもかかわらず the absence of any good 証拠.

'The RECOVERY 裁判，公判 has shown that hydroxychloroquine is not an 効果的な 治療 in 患者s hospitalised with COVID-19.?

'Although it is disappointing that this 治療 has been shown to be 効果のない／無能な, it does 許す us to 焦点（を合わせる） care and 研究 on more 約束ing 麻薬s.'?

US President Trump has hailed hydroxychloroquine as a game changer since March. Last month he revealed he was taking it as a preventative to stop him catching Covid

US 大統領 Trump has あられ／賞賛するd hydroxychloroquine as a game changer since March. Last month he 明らかにする／漏らすd he was taking it as a preventative to stop him catching Covid?

WHY IS HYDROXY-CHLOROQUINE CONTROVERSIAL??

Hydroxychloroquine - branded as Plaquenil - is a cheap 麻薬 that has been used to 妨げる malaria and 扱う／治療する lupus and rheumatoid arthritis for １０年間s.

It was touted as a wonder 麻薬 by Donald Trump にもかかわらず no 証拠 it could 扱う／治療する Covid-19.?

Hope was 誘発するd 早期に on in the 危機 when a French 熟考する／考慮する 示唆するd the 麻薬 could have both antiviral and anti-inflammatory 影響s.

It 誘発する／引き起こすd a flurry of 研究 across the world, the 裏書，是認 from Trump and 緊急 authorization from US regulators.

The RECOVERY 裁判，公判 is the first randomised 熟考する／考慮する to 供給する 固める／コンクリート 証拠 about the 麻薬.

The results will likely have a knock-on 影響 around the globe, where tens of thousands of coronavirus 患者s are still 存在 定める／命ずるd hydroxychloroquine.?

主要な doctors have also 警告するd the 麻薬 can 原因（となる） 厳しい 味方する 影響s, and can even throw off the 過程 that makes the heart （警官の）巡回区域，受持ち区域 in time.

One 裁判，公判 in Brazil was stopped short because so many of the 入会させるd coronavirus 患者s given the 麻薬 developed these arrhythmias (異常な heartbeats).

によれば WebMD, 味方する 影響s may 含む:?

  • Nausea, vomiting, loss of appetite, diarrhea, dizziness, or 頭痛
  • Slow heartbeat, symptoms of heart 失敗 (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden 負わせる 伸び（る）)
  • Mental/mood changes (such as 苦悩, 不景気, rare thoughts of 自殺, hallucinations)
  • 審理，公聴会 changes (such as （犯罪の）一味ing in the ears, 審理，公聴会 loss), 平易な bruising/bleeding
  • 調印するs of 感染 or 肝臓 病気
  • Muscle 証拠不十分, unwanted/uncontrolled movements (含むing tongue/直面する twitching), hair loss, hair/肌 color changes
  • Low 血 sugar, 厳しい dizziness, fainting, 急速な／放蕩な/不規律な heartbeat, seizures.
宣伝

発表するing the findings today,?Professor Landray said: 'We have 結論するd that there is no 有益な 影響 of hydroxychloroquine in 患者s hospitalised with COVID-19.?

'We have therefore decided to stop 入会させるing 関係者s to the hydroxychloroquine arm of the RECOVERY 裁判，公判 with 即座の 影響.???

'There was no 重要な difference in the 最初の／主要な endpoint of 28-day mortality. There was also no 証拠 of 有益な 影響s on hospital stay duration or other 結果s.

'These data convincingly 支配する out any meaningful mortality 利益 of hydroxychloroquine in 患者s hospitalised with COVID-19.'?

Professor Horby and Professor Landray were supposed to be 'blinded' from the results from RECOVERY - which is also looking into four other 約束ing Covid therapies - until July.

But 関心s about the safety of hydroxychloroquine began 開始するing in late May when a 議論の的になる paper published in The Lancet 支配するd the tablets raised the 危険 of death in Covid 患者s.

The paper - which has now been 撤回するd after 存在 （刑事）被告 of using sloppy data - spooked 研究 teams around the world into 一時停止するing 裁判，公判s of the 麻薬, 含むing the 世界保健機構's SOLIDARITY 熟考する／考慮する and two separate 裁判，公判s in the UK.?

Professor Horby said the 関心s about the anti malaria 麻薬's safety '原因（となる）d us to look at the blinded data more quickly than we would have.'

The UK's 麻薬s 監視者, the 薬／医学s and Healthcare 製品s Regulatory 機関 (MHRA), 一時停止するd 新規採用 for the COPCOV and 原則 裁判，公判s last week on the 支援する of the Lancet paper's findings.

COPCOV is a separate Oxford 熟考する／考慮する 存在 carried out と一緒に Brighton University,?調査／捜査するing whether the malaria tablets can 妨げる corona ウイルス 感染 in the first place.

Hydroxychloroquine will be?given to?more than 40,000 frontline healthcare 労働者s from Europe, Africa, Asia and South America.??

The COPCOV 研究員s believe their 研究 is 安全な because it does not 伴う／関わる 患者s already ill with coronavirus. They remain 確信して their 熟考する／考慮する will go ahead.

The MHRA also 停止（させる）d the use of hydroxychloroquine in the 原則 裁判，公判, which is 熟考する／考慮するing people 老年の 50 to 64 who have COVID-19 symptoms and a chronic health 条件 such as heart 病気, 喘息 or 癌.

It is thought that the malaria 麻薬 will be pulled from the 熟考する／考慮する on the 支援する of the results from the RECOVERY 裁判，公判.

The 世界保健機構 said on Wednesday it was ready to 再開する its SOLIDARITY 裁判，公判, but it has been advised against doing so by the RECOVERY 研究員s.

The Lancet 熟考する／考慮する was a 'retrospective observational' 熟考する／考慮する, using a data 始める，決める from an analytics 会社／堅い, to see what 影響s the 麻薬 had had on some COVID-19 患者s, compared to those who did not get it.?

They are 女性 than randomised 熟考する／考慮するs, like RECOVERY, which are seen as the gold 基準 in 研究 because they 無作為に 割り当てる a 治療 to one group of people and a 模造の to another group so that the two can be compared.?

大統領 Trump was の中で the first to wax lyrical about the possible 利益s of hydroxychloroquine for coronavirus 患者s in March.

早期に lab 熟考する／考慮するs in petri dishes showed the 麻薬 could fend off coronavirus and 妨げる it from replicating.

In the absence of （疑いを）晴らす scien tific 証拠, some 当局 and 消費者s are buying up 在庫／株s of the 麻薬 in 事例／患者 it turns out to be 効果的な.?

Britain, for example, was spending millions of 続けざまに猛撃するs 本体，大部分／ばら積みの-buying tablets in 事例／患者 they 証明するd to be 効果的な.

The 麻薬 is also 存在 定期的に used in 中国 and India and has been 認可するd for 緊急 use in 厳しく ill 患者s in the US.?

?

撤回するd Lancet paper which 警告するd against Covid-19 麻薬 支持する／優勝者d by Donald Trump ゆらめくs 告訴，告発s of political point-得点する／非難する／２０ing and 疑わしい data

A 'scandalous' and now 撤回するd 医療の 熟考する／考慮する which 警告するd against using a 麻薬 支持する／優勝者d by Donald Trump has ゆらめくd 告訴，告発s of political-point 得点する／非難する／２０ing.??

The paper's （人命などを）奪う，主張する that?hydroxychloroquine 増加するs the 危険 of death in Covid-19 患者s has been used by 競争相手s as a stick to （警官の）巡回区域，受持ち区域 the US 大統領, who has himself been taking the 麻薬 and あられ／賞賛するd it a 'game-changer' in the war on coronavirus.

開始するing 疑問s over the 熟考する／考慮する's reliability 最高潮に達するd yesterday when the authors 撤回するd their 熟考する／考慮する from the Lancet 医療の 定期刊行物, whose 編集（者）の 基準s have also been thrown into question.

The climbdown has dredged up ぐずぐず残る 関心s the findings have become a political football to 土台を崩す the 大統領.

Dr Mandeep Mehra, of Harvard Medical School, was the study's lead author
University Hospital Zurich's Dr?Frank Ruschitzka was among the co-authors to sign the retraction
Dr Amit Patel, of the University of Utah, also co-signed the retraction

The 熟考する／考慮する was 撤回するd by three of its four authors: Dr Mandeep Mehra, of Harvard 医療の School, Dr Frank Ruschitzka from University Hospital Zurich and Dr Amit Patel of the University of Utah (pictured from left to 権利) all co-調印するd the retraction?

The 研究 has also been blighted by 批評 of sloppy data by the small 私的な company which 行為／行うd the 分析.

The 熟考する／考慮する made waves not just in the 科学の community, but also in Washington where Trump's critics 軽蔑（する）d him for 押し進めるing the 麻薬 for coronavirus 患者s.

Dr Carlos Chaccour, an 感染性の 病気 専門家 at the Barcelona 学校／設ける of 全世界の Science, believes the paper muddied the 科学の discourse and has been used by 競争相手s to 得点する／非難する／２０ political points.?

'There was 抱擁する political polarisation about hydroxychlorioquine, politics became mixed in with 政策,' he told the 後見人.

'So there's people defending hydroxychloroquine because they like Donald Trump, and people …に反対するing it because they don't like Donald Trump.'

The paper's lead author Dr Mandeep Mehra of Harvard 医療の School said in a 最近の interview the 熟考する／考慮する was 誘発するd by 'amazement' at how 政府s were touting the 麻薬.

The study authors published a retraction of their research on June 4, less than a month after the original article was published. They revealed that their data could not be reviewed and apologized for any 'embarrassment or inconvenience that this may have caused'

The 熟考する／考慮する authors published a retraction of their 研究 on June 4, いっそう少なく than a month after the 初めの article was published. They 明らかにする／漏らすd that their data could not be reviewed and わびるd for any '当惑 or inconvenience that this may have 原因（となる）d'?

He told FranceSoir: 'We were amazed at the 普及した use of hydroxychloroquine and chloroquine around the world and in particular the way 政府 機関s were 押し進めるing for it without much 証拠.'??

Little is known of Dr Mehra's political 同盟s, but he has 'liked' tweets 非難するing 'political leaders' for 押し進めるing hydroxychloroquine.?

Along with Dr Amit Patel of the University of Utah and Dr F 階級 Ruschitzka of the University Hospital Zurich, Dr Mehra 問題／発行するd an 陳謝 to the Lancet.??

But since the retraction, Dr Mehra has not commented 公然と, which raised eyebrows from a 最高の，を越す scientist.??

Professor Karol Sikora, a former World Health Organisation director, told MailOnline: 'The problem I think in trying to sort it out is nobody's going to 収容する／認める to anything.?

'The author's gone to ground, which is わずかに unusual. You'd think he be out there.'

He 追加するd: 'I think there's some sort of スキャンダル.'?

The fourth author, Dr Sapan Desai, CEO of the 私的な company Surgisphere which 収集するd the data, has not spoken 公然と.??

The reliability of Surgisphere has been 選ぶd apart in 最近の days, with more than 120 目だつ scientists raising questions about the data used in the 熟考する／考慮する.

Several of the company's handful of 従業員s appear to be 厳しく under-qualified.?

One, 名簿（に載せる）／表（にあげる）d as the science editor, is a 十分な-time science fiction writer while another, the marketing (n)役員／(a)執行力のある, is an adult model and events hostess, によれば the 後見人.??

Since the paper was published by the Lancet, the 研究 has been under outside review.

Surgisphere 辞退するd to 移転 its data to the auditors, 特記する／引用するing 患者 privacy, 主要な to the review to be 削減（する） short and the article 撤回するd.?

'We can no longer vouch for the veracity of the 最初の／主要な data sources,' the authors wrote to The Lancet in their retraction.?

The Lancet itself has been （刑事）被告 of political partisanship after 勧めるing readers in a stinging 編集（者）の to 投票（する） out Trump.

Last month, it wrote: 'Americans must put a 大統領，／社長 in the Wh ite House come January, 2021, who will understand that public health should not be guided by 同志／支持者 politics.?

Prof Chris 議会s, School of Psychology, Cardiff University Brain 研究 Imaging Centre, said last night: 'It is 権利 that these articles were 撤回するd.?

'However, the 失敗 to 解決する such basic 関心s about the data during the course of normal peer review raises serious questions about the 基準 of editing at the Lancet and NEJM ― 表面上は two of the world's most prestigious 医療の 定期刊行物s.?

'If these 定期刊行物s take 問題／発行するs of reproducibility and 科学の 正直さ as 本気で as they （人命などを）奪う，主張する, then they should forthwith 服従させる／提出する themselves and their 内部の review 過程s to an 独立した・無所属 調査.'