The worm that can NEVER get drunk: Mutant animal created by scientists in 企て，努力，提案 to 扱う／治療する アル中患者s
- Created worm with alcohol 封鎖するing 分子
- Tiny worm loses the ability to wiggle when drunk
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研究員s have created a mutant worm that can never get drunk.
They 挿入するd a 分子 that can 完全に 封鎖する the 影響s on alcohol into the Caenorhabditis elegans.
The tiny worm was chosen because it loses the ability to wiggle when drunk.
The worms used in the 熟考する／考慮する, Caenorhabditis elegans slow their はうing with いっそう少なく wriggling from 味方する to 味方する when drunk
HOW TO SPOT A DRUNK WORM
The worms used in the 熟考する／考慮する, Caenorhabditis elegans, model intoxication 井戸／弁護士席, the 研究員s say.
Alcohol 原因（となる）s the worms to slow their はうing with いっそう少なく wriggling from 味方する to 味方する.
The intoxicated worms also stop laying eggs, which build up in their 団体／死体s and can be easily counted.
Unfortunately, C. elegans are not as ideal for 熟考する／考慮するing the other areas of alcohol 中毒, but mice make an excellent model.
The 修正するd human BK channel used in the 熟考する／考慮する, which is based on a 突然変異 discovered by lead author and 卒業生（する） student Scott Davis, could be 挿入するd into mice.
The University of Texas at Austin scientists 遂行するd this feat by 挿入するing a 修正するd human alcohol 的 into the worms, as 報告（する）／憶測d this week in The 定期刊行物 of Neuroscience.
Jon Pierce-Shimomura, who led the 研究, said it could even be used to develop a 'James 社債' 麻薬 someday, which would enable a 秘かに調査する to drink his 対抗者 under the （米）棚上げする／（英）提議する, without getting drunk himself.
Such a 麻薬 could also 潜在的に be used to 扱う／治療する アル中患者s, since it would 中和する／阻止する the intoxicating and 潜在的に （麻薬）常用者ing 影響s of the alcohol.
'This is the first example of altering a human alcohol 的 to 妨げる intoxication in an animal,' he said.
An alcohol 的 is any neuronal 分子 that 貯蔵所d alcohol, of which there are many.
One important 面 of this 修正するd alcohol 的, a neuronal channel called the BK channel, is that the 突然変異 only 影響する／感情s its 返答 to alcohol.
The BK channel typically 規制するs many important 機能（する）／行事s 含むing activity of neurons, 血 大型船s, the respiratory tract and bladder.
The alcohol-insensitive 突然変異 does not 混乱に陥れる／中断させる these 機能（する）／行事s at all.
'We got pretty lucky and 設立する a way to make the channel insensitive to alcohol without 影響する／感情ing its normal 機能（する）／行事,' says Pierce-Shimomura.
when sober, the Caenorhabditis elegans worm is able to wiggle (left), but once intoxicated, it straightens up.
The scientists believe the 研究 has 可能性のある 使用／適用 for 扱う／治療するing people （麻薬）常用者d to alcohol.
'Our findings 供給する exciting 証拠 that 未来 製薬のs might 目的（とする） at this 部分 of the alcohol 的 to 妨げる problems in alcohol 乱用 disorders,' says Pierce-Shimomura.
'However, it remains to be seen which 面s of these disorders would 利益.'
Unlike 麻薬s such as コカイン, which have a 明確な／細部 的 in the nervous system, the 影響s of alcohol on the 団体／死体 are コンビナート／複合体 and have many 的s across the brain.
The さまざまな other 面s of alcohol 中毒, such as 寛容, craving and the symptoms of 撤退, may be 影響（力）d by different alcohol 的s.
The worms used in the 熟考する／考慮する, Caenorhabditis elegans, model intoxication 井戸／弁護士席.
研究員s saif the work could even be used to develop a 'James 社債' 麻薬 someday, which would enable a 秘かに調査する to drink his 対抗者 under the （米）棚上げする／（英）提議する, without getting drunk himself.
Alcohol 原因（となる）s the worms to slow their はうing with いっそう少なく wriggling from 味方する to 味方する.
The intoxicated worms also stop laying eggs, which build up in their 団体／死体s and can be easily counted.
Unfortunately, C. elegans are not as ideal for 熟考する／考慮するing the other areas of alcohol 中毒, but mice make an excellent model.
The 修正するd human BK channel used in the 熟考する／考慮する, which is based on a 突然変異 discovered by lead author and 卒業生（する） student Scott Davis, could be 挿入するd into mice.
These 修正するd mice would 許す scientists to 調査／捜査する whether this particular alcohol 的 also 影響する／感情s 寛容, craving and other symptoms 関連した to humans.
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