- A New Jersey 居住（者） is the first woman to receive a pig 腎臓 移植（する）
- Lisa Pisano, 54, is only the second 患者 to receive a 遺伝子-edited pig 腎臓
- READ MORE: Man, 62, in Boston is given a genetically 修正するd PIG's 腎臓
A?New Jersey?woman with just weeks to live was given a first-of-its-肉親，親類d 操作／手術 that saw her receive both a pig 腎臓 移植（する） and an implantation of a heart 装置.?
Lisa Pisano, 54, was getting 'sicker and sicker' from congestive heart and 腎臓 失敗, which left her unable to get a 伝統的な 組織／臓器 移植（する）.?
However, as Ms Pisano ran out of 選択s, doctors at NYU Langone Health in New York City?工夫するd a novel two-part 操作／手術: Implant a mechanical pump to keep her heart （警官の）巡回区域，受持ち区域ing and days later 移植（する） a 腎臓 from a genetically 修正するd pig.
Her 外科 was successful and the new 腎臓 began making urine almost すぐに, doctors said, recounting 元気づけるs in the operating room. The 患者 has also started to walk, something that was nearly impossible before her 手続き.??
Ms Pisano is only the second 患者 to receive a pig 腎臓, に引き続いて a 目印 移植（する） at Massachusetts General Hospital?in Boston last month, and she is the first person to を受ける a combination heart 手続き and animal 組織／臓器 移植（する）.
This family photo shows Lisa Pisano, 権利, and her daughter, Brittany Harvill
Ms Pisano told the Associated 圧力（をかける）: 'I was at the end of my rope. I just took a chance. And you know, worst 事例／患者 シナリオ, if it didn't work for me, it might have worked for someone else and it could have helped the next person.
'It's been transformative.'??
The team 公式文書，認めるd there have been no 文書d instances of anyone with a mechanical heart pump receiving an 組織／臓器 移植（する） of any 肉親，親類d.
'It is incredib le to consider the 科学の 業績／成就s that have led to our ability to save Lisa’s life, and what we are 努力するing to do as a society for everyone in need of a life-saving 組織／臓器,' said Dr Robert Montgomery, director of the NYU Langone 移植（する） 学校／設ける.
He 追加するd: 'This could not have been done without the dedication and 技術 of the many talented 内科医s, 研究員s, nurses, health 行政官／管理者s, and perioperative care teams at NYU Langone Health, and the 非常に／多数の 開拓するs who （機の）カム before us.'
事前の to her 手続き, it was discovered that Ms Pisano had high levels of harmful antibodies to human tissues, which made it difficult to find a match for a human 腎臓 移植（する）.?
Her 医療の team said it would have taken years.?
However, her antibodies were not harmful to 遺伝子-edited pig 組織／臓器s.?
In this photo 供給するd by NYU Langone Health, 外科医s operate on Lisa Pisano at the hospital in New York on April 12, 2024. Doctors 移植（する）d a pig 腎臓 into Pisano, who was 近づく death, part of a 劇の pair of 外科s that also 含むd a 直す／買収する，八百長をする for her failing heart
In this photo 供給するd by NYU Langone Health, a 外科医 解除するs the 遺伝子-edited pig 腎臓 out of Lisa Pisano's abdomen to check its 機能（する）／行事
In this photo 供給するd by NYU Langone Health, a 遺伝子-edited pig 腎臓 with thymus is 除去するd from its 輸送（する） コンテナ to be 用意が出来ている for transplantation at the hospital
Ms Pisano had gone into cardiac 逮捕（する） 多重の times as a result of her 条件 and had gotten too weak to even play with her grandchildren.??
'With this 外科 I get to see my wife smile again,' Ms Pisano's husband, Todd Pisano, said.?
There's no way to 予報する Ms Pisano's long-称する，呼ぶ／期間／用語 結果 but she has shown no 調印するs of 組織／臓器 拒絶 so far, Dr Montgomery said.?
The team 公式文書，認めるd her 生き残り 'could be 手段d in days or weeks.'?
The first-of-its-肉親，親類d feat took a 一連の 操作／手術s over the course of nine days.?
In the first 手続き, 成し遂げるd on April 4, 外科医s implanted the heart pump, also known as a left ventricular 補助装置 装置 (LVAD). This helps pump 血 from the heart's lower 議会s to the 残り／休憩（する） of the 団体／死体 and is typically used in 患者s who are ineligible for a 心臓移植.?
On 普通の／平均（する）, this 操作／手術 takes about four to eight hours. Ms Pisano did not qualify for an LVAD on its own because she was を受けるing 透析 for her 腎臓 失敗, which 弱めるd her 団体／死体.
However, because she was going to get a pig 腎臓 移植（する）, doctors went ahead with the LVAD 手続き.?
Dr Nader Moazami, 長，指導者 of the 分割 of Heart and 肺 Transplantation and Mechanical Circulatory Support at NYU, who 成し遂げるd the LVAD 手続き, said: 'Without the 可能性 of a 腎臓 移植（する）, she would not have been 適格の as a 候補者 for an LVAD 予定 to the high mortality in 患者s on 透析 with heart pumps.'?
'This unique approach is the first time in the world that LVAD 外科 has been done on a 透析 患者 with a その後の 計画（する） to 移植（する） a 腎臓.
'The 手段 for success is a chance at a better 質 of life and to give Lisa more time to spend with her family.'
On April 12, a team of 外科医s led by Dr Montgomery 成し遂げるd the xenotransplant, a 移植（する） of an 組織／臓器 between different 種類.?
The 寄贈者 pig's thymus （分泌する為の）腺, which is 責任がある 免疫の 機能（する）／行事s, was placed under the covering of the 腎臓 to 減ずる the 見込み of 拒絶.?
This is a 選び出す／独身-遺伝子 modification known as UThymoKidney. It was 認可するd with 緊急 authorization from the FDA.
'By using pigs with a 選び出す／独身 genetic modification, we can better understand the 役割 one 重要な stable change in the genome can have in making xenotransplantation a viable 代案／選択肢,' Dr Montgomery said.?
He 追加するd: 'Since these pigs can be bred and do not 要求する cloning like more-コンビナート／複合体 遺伝子 edits, this is a 維持できる, scalable 解答 to the 組織／臓器 不足. If we want to start s aving more lives quickly, using より小数の modifications and 医薬s will be the answer.'
Lisa Pisano steps 支援する into her bed while 回復するing from her 外科s at NYU Langone Health in New York on Monday, April 22, 2024
Lisa Pisano looks at photos of her dog after her 外科s at NYU Langone Health in New York on Monday, April 22, 2024
Other 移植（する） 専門家s are closely watching how the 患者 fares.
Dr Tatsuo Kawai of 集まり General, who 成し遂げるd the first pig 腎臓 移植（する） last month, said: 'I have to congratulate them.'
He 公式文書，認めるd 公式文書，認めるd his own pig 腎臓 患者 was healthier 全体にわたる going into his 操作／手術 than NYU's 患者, so NYU had 追加するd challenges.?
Dr Kawai said: 'When the heart 機能（する）／行事 is bad, it's really difficult to do a 腎臓 移植（する）.'
More than 100,000 people are on the US 移植（する） waiting 名簿（に載せる）／表（にあげる）, most who need a 腎臓, and thousands die waiting.?
In hopes of filling the 不足 of 寄付するd 組織／臓器s, several biotech companies are genetically 修正するing pigs so their 組織／臓器s are more humanlike and いっそう少なく likely to be destroyed by people's 免疫の systems.
NYU and other 研究 teams have 一時的に 移植（する）d pig 腎臓s and hearts into brain-dead 団体／死体s, with 約束ing results.?
The University of Maryland also 移植（する）d pig hearts into two men who had no other feasible 医療の 選択s.?Both died within months.
But 集まり General's pig 腎臓 移植（する） last month raised new hopes. Dr Kawai said the 患者, Richard 'Rick' Slayman, experienced an 早期に 拒絶 脅す but bounced 支援する enough to go home earlie r this month and still is faring 井戸／弁護士席 five weeks 地位，任命する-移植（する）.?
